Glucose Intolerance in Patients on Long-term Intermittent Dialysis

Article1 August 1966Glucose Intolerance in Patients on Long-term Intermittent DialysisROGER H. HUTCHINGS, M.D., ROBERT M. HEGSTROM, M.D., BELDING H. SCRIBNER, M.D.ROGER H. HUTCHINGS, M.D., ROBERT M. HEGSTROM, M.D., BELDING H. SCRIBNER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-275 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn abnormality in glucose metabolism in uremia was recognized in 1916 by Myers and Bailey (1). This abnormality was confirmed by several workers (2, 3), and since the study in 1958 by Perkoff and associates (4), a number of recent reports characterizing the abnormality and speculating on the pathogenesis have appeared (5-9).Previous studies of glucose intolerance in uremia have often included azotemic patients with various basic diseases who were or had recently been severely ill with the symptoms or complications of uremia (4-7). It has been difficult to decide from these reports whether the glucose intolerance is the result...References1. MYERSBAILEY VCCV: The Lewis and Benedict method for the estimation of blood sugar, with some observations obtained in disease. J. Biol. Chem. 24: 147, 1916. CrossrefGoogle Scholar2. WILLIAMSHUMPHREYS JREM: Clinical significance of blood sugar in nephritis and other diseases. Arch. Intern. Med. (Chicago) 23: 537, 1919. CrossrefGoogle Scholar3. LINDERHILLERVAN SLYKE GCADD: Carbohydrate metabolism in nephritis. J. Clin. Invest. 1: 247, 1924-25. CrossrefGoogle Scholar4. PERKOFFTHOMASNEWTONSELLMANTYLER GTCLJDJCFH: Mechanism of impaired glucose tolerance in uremia and experimental hyperazotemia. Diabetes 7: 375, 1958. CrossrefMedlineGoogle Scholar5. COHEN BD: Abnormal carbohydrate metabolism in renal disease. Blood glucose unresponsiveness to hypoglycemia, epinephrine and glucagon. Ann. Intern. Med. 57: 204, 1962. LinkGoogle Scholar6. 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HAMPERSDOAKSOELDENERMERRILL CLPBJSJP: Correctable carbohydrate intolerance in uremia (abstract). Clin. Res. 2: 307, 1965. Google Scholar38. TENCKHOFFBOENJEBSENSPIEGLER HASTRHJH: Polyneuropathy in chronic renal insufficiency. JAMA 192: 1121, 1965. CrossrefMedlineGoogle Scholar39. RENOLDWINEGRAD AEAI: Insulin action: effects on individual tissues, in Diabetes, edited by WILLIAMS, R. H. Paul B. Hoeber Inc., New York, 1960, p. 129. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROGER H. HUTCHINGS, M.D.; ROBERT M. HEGSTROM, M.D.; BELDING H. SCRIBNER, M.D.Affiliations: Seattle, WashingtonFrom the Department of Medicine, University of Washington School of Medicine, Seattle, Wash.This study was supported in part by grant AM-06741, the National Institutes of Health, and a portion of the work was conducted on the Clinical Research Center Facility supported by grant 8M01 FR-37, the National Institutes of Health, Bethesda, Md.Dr. Hutchings was supported by a Postdoctoral Fellowship and Dr. Hegstrom by a Special Fellowship from the U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to Belding H. Scribner, M. D., Department of Medicine, University of Washington School of Medicine, Seattle, Wash. 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EPSTEIN, M.D.Natural History of Uremic Polyneuropathy and Effects of DialysisChanges in glucose and insulin metabolism induced by dialysis in patients with chronic uremiaThe effect of potassium on the imparired glucose tolerance in chronic uremiaAzotemia and Glucose IntoleranceJAMES M. CERLETTY, M.D., NORMAN H. ENGBRING, M.D.ROLE OF INSULIN IN GLUCOSE INTOLERANCE IN URÆMIA 1 August 1966Volume 65, Issue 2Page: 275-285KeywordsFellowshipsGlucagonGlucose intoleranceGlucose metabolismInsulinMedical dialysisMedical servicesPathogenesisResearch facilitiesUrea ePublished: 1 December 2008 Issue Published: 1 August 1966 PDF downloadLoading ...