Key result
Plasma PAI-1 levels are increased in patients with nonalcoholic steatohepatitis.
Observational (n=85)
This study investigates the correlation between plasma PAI-1 levels and liver histopathology in NAFLD patients to explore potential molecular mediators of increased cardiovascular risk.
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Hypothesis-generating for PAI-1 as cardiovascular risk mediator in NASH; prospective studies required before clinical consideration.
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Targher et al. (2007) conducted an observational in Nonalcoholic fatty liver disease (NAFLD) (n=85). Nonalcoholic Steatohepatitis was evaluated on Correlation of PAI-1 with liver histopathology independent of metabolic syndrome features. Plasma PAI-1 levels are increased in patients with nonalcoholic steatohepatitis.
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