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July 1, 1968Circulation

Intramural and Pericapillary Distribution of Lipids in Gingival Tissue of Patients with Carbohydrate-Induced Hyperglyceridemia

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Why the study?

Are there histological abnormalities in the gingival capillaries of patients with carbohydrate-induced hyperglyceridemia?

Population

33 subjects including 16 patients with carbohydrate-induced hyperglyceridemia, 4 with essential familial…

Comparison

Gingival biopsy to assess histological… vs Healthy normolipemic subjects, patients with…

Design

Cross-sectional

Authors

JCJohn L. CornogYale New Haven HospitalWFWilliam T. FittsHospital of the University of PennsylvaniaPKPeter T. KuoGeneral / Preventive / Lipids

Discussion

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Implication

Supports lipid deposition without microangiopathy in untreated hyperglyceridemia; hypothesis-generating cross-sectional data leaves open clinical relevance.

Structured PICO

Are there histological abnormalities in the gingival capillaries of patients with carbohydrate-induced hyperglyceridemia?

P
Population
33 subjects including 16 patients with carbohydrate-induced hyperglyceridemia, 4 with essential familial hypercholesteremia, 5 with controlled hyperglyceridemia (on low carbohydrate diet for 6 to 26 months), and 8 healthy normolipemic subjects.
I
Intervention
Gingival biopsy to assess histological abnormalities in capillaries.
C
Comparator
Healthy normolipemic subjects, patients with essential familial hypercholesteremia, and patients with controlled hyperglyceridemia.
O
Outcome
Presence of Oil Red O-stainable lipid material in and around capillary walls and capillary basement membrane thickening.surrogate

Sustained chylomicronemia in carbohydrate-induced hyperglyceridemia is associated with intramural and pericapillary lipid deposition in gingival tissue without diabetic-type microangiopathy.

Cite This Study

Cornog et al. (1968) studied this question.

synapsesocial.com/papers/6a84436613a05c0de00ba5dchttps://doi.org/10.1161/01.cir.38.1.201
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders1967 · 1,911 citations
  2. 2Carbohydrate Metabolism in Two Forms of Hyperglyceridemia *1964 · 133 citations
  3. 3Histological and Histochemical Uses of Periodic Acid1948 · 1,364 citations