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July 10, 1967JAMA

Hyperglyceridemia in coronary artery disease and its management

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Key result

More than 90% of 286 patients with atherosclerosis had hyperglyceridemia derived from carbohydrate sensitivity, which was controlled by a sugar-free diet with 125 to 150 g of starches.

Why the study?

Does a sugar-free diet control hyperglyceridemia in patients with atherosclerosis?

Population

286 patients with atherosclerosis

Design

Cohort

Authors

PKP. T. Kuo

Discussion

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Implication

Hyperglyceridemia in atherosclerosis may often reflect carbohydrate sensitivity; leaves open whether sugar-free diets improve outcomes in randomized trials.

Study Design

Type

Observational (n=286)

Structured PICO

Does a sugar-free diet control hyperglyceridemia in patients with atherosclerosis?

P
Population
286 patients with atherosclerosis evaluated for etiologic classification of hyperlipidemia.
E
Exposure
Sugar-free diet, with a carbohydrate allowance of 125 to 150 gm supplied as starches
O
Outcome
Control of abnormal metabolism (hyperglyceridemia)surrogate

In patients with atherosclerosis, hyperglyceridemia is frequently driven by carbohydrate sensitivity and can be effectively managed with a sugar-free, starch-based diet.

Cite This Study

P. T. Kuo (1967) conducted an observational in Atherosclerosis (n=286). Carbohydrate intake was evaluated on Hyperglyceridemia derived from increased endogenous lipogenesis from carbohydrate. More than 90% of 286 patients with atherosclerosis had hyperglyceridemia derived from carbohydrate sensitivity, which was controlled by a sugar-free diet with 125 to 150 g of starches.

synapsesocial.com/papers/6a993b7652d74751e8200c12https://doi.org/10.1001/jama.201.2.87
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Current Metabolic-Genetic Interrelationship in Human Atherosclerosis1968 · 30 citations
  2. 2Hypertriglyceridemia, Diabetes Mellitus, and Coronary Vessel Disease1969 · 65 citations
  3. 3Risk factors for coronary artery disease: a study comparing hypercholesterolaemia and hypertriglyceridaemia in angiographically characterized patients1989 · 20 citations
  4. 4Intramural and Pericapillary Distribution of Lipids in Gingival Tissue of Patients with Carbohydrate-Induced Hyperglyceridemia1968 · 3 citations
  5. 5Glucose intolerance, insulin resistance and metabolic syndrome in patients with stable angina pectoris. Obesity predicts coronary atherosclerosis and dysglycemia2008 · 14 citations