Enhanced norepinephrine sensitivity in renal arteries at elevated transmural pressure

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Population

Cannulated small arteries isolated from dog kidneys

Comparison

Norepinephrine at elevated transmural pressures vs Norepinephrine at lower transmural pressure

Design

Preclinical

Authors

Discussion

May modulate vascular reactivity in animal models; leaves open translation to human vasopressor responses or hypertension.

Population

Cannulated small arteries isolated from dog kidneys

Intervention

Norepinephrine at elevated transmural pressures (100 and 140 mmHg)

Comparator

Norepinephrine at lower transmural pressure (60 mmHg)

Outcome

Electrical and mechanical responses of vascular smooth muscle (depolarization and vessel sensitivity)surrogate

Transmural pressure in a blood vessel may be an important determinant of its sensitivity to vasoactive agonists like norepinephrine.

Lombard et al. (1990) studied this question.

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