Key result
Intra-arterial norepinephrine and angiotensin selectively drive arterial over venous vasoconstriction.
Why the study?
The relative constrictor capacity of the arterial versus venous sides of the kidney vasculature and the effects of norepinephrine and angiotensin on renal vascular resistance were not fully characterized.
Population
Intact kidneys of anesthetized dogs perfused at constant blood flow
Comparison
Intra-arterial norepinephrine and angiotensin administration and sympathetic nerve stimulation effects on renal vessels
Design
Preclinical experimental study with direct vascular measurements
Authors
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Suggests predominant arterial constriction in experimental models; leaves open translation to human vasoregulation or therapy.
In the canine kidney, vasomotor adjustments to norepinephrine and angiotensin occur predominantly on the arterial rather than the venous side.
Zimmerman et al. (1964) studied this question. Norepinephrine and angiotensin was evaluated on Changes in perfusion pressure (PP) and small vein pressure (SVP). Intra-arterial administration of norepinephrine and angiotensin produced large increases in perfusion pressure and small increments in small vein pressure, indicating greater arterial constrictor capacity.
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