Key result
Angiotensin II and norepinephrine cause severe focal afferent arteriolar constriction in rats independent of autoregulation.
Authors
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Indicates direct, pressure-independent afferent arteriolar constriction by Ang II and NE; leaves open human translation and clinical relevance.
S. K. Wilson (1986) studied this question. Angiotensin II and norepinephrine vs. Normal saline was evaluated on Afferent arteriolar constriction and vessel diameter. Angiotensin II and norepinephrine caused severe focal constriction of afferent arterioles in rats, independent of a pressure-induced autoregulatory response.
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