Key result
ACE I/D polymorphism and serum ACE activity did not differ between neonates with transient tachypnea or respiratory distress syndrome and control infants.
Why the study?
Is there a relationship between angiotensin-converting enzyme (ACE) I/D polymorphism, ACE activity, and the development of transient tachypnea of neonate or respiratory distress syndrome?
Case-Control (n=60)
Is there a relationship between angiotensin-converting enzyme (ACE) I/D polymorphism, ACE activity, and the development of transient tachypnea of neonate or respiratory distress syndrome?
ACE I/D polymorphism and serum ACE activity do not appear to be associated with the development of transient tachypnea of the neonate or respiratory distress syndrome.
No association in case-control data does not support ACE testing in neonatal respiratory distress; leaves open alternative genetic or mechanistic pathways.
BACKGROUND: Transient tachypnea of neonate (TTN) and respiratory distress syndrome (RDS) of the newborn are the most common cause of early respiratory distress in the immediate neonatal period. There is increasing evidence to support the role for the activation of the renin angiotensin system during acute lung injury. OBJECTIVES: The purpose of this study was to determine if there is a relationship between angiotensin-converting enzyme (ACE) I/D polymorphism, ACE activity and TTN and respiratory distress syndromes. METHODS: Nineteen neonates with TTN, 20 neonates with RDS and 21 control infants are studied for ACE polymorphism and serum ACE activity. RESULTS: Twenty six (43.3%) patients have DD polymorphism, 19 (31.7%) patients have ID polymorphism and 15 (25%) patients have II polymorphism. Serum ACE activity is 43.5 ± 1.8 (40-46) U/L in DD, 31.5 ± 2.3 (28-36) U/L in ID and 22.1 ± 2.1(19-46) U/L in II patient. CONCLUSIONS: The study could not find any difference in DD alleles and ACE activity between control group and TTN group. ACE polymorphism was not different between RDS group and control group in this study.
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Satar et al. (2012) conducted a case-control in Transient tachypnea of neonate and respiratory distress syndrome (n=60). Angiotensin-converting enzyme (ACE) I/D polymorphism and ACE activity vs. Control infants was evaluated on Difference in DD alleles and ACE activity between groups. ACE I/D polymorphism and serum ACE activity did not differ between neonates with transient tachypnea or respiratory distress syndrome and control infants.
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