Key result
ACE I/D polymorphism was significantly associated with an increased risk of acute respiratory distress syndrome (OR 1.57; 95% CI 1.30-1.89; P<0.00001).
Why the study?
Does ACE I/D polymorphism increase the risk of acute respiratory distress syndrome (ARDS)?
Meta-Analysis (n=5,218)
Does ACE I/D polymorphism increase the risk of acute respiratory distress syndrome (ARDS)?
Odds Ratio: 1.57 (95% CI 1.3–1.89)
p-value: p=<0.00001
The ACE I/D polymorphism is associated with an increased susceptibility to ARDS, particularly in Caucasian and adult populations.
May aid ARDS risk stratification in Caucasian adults; leaves open causal mechanisms and therapeutic implications.
BACKGROUND: Some studies have assessed the association between angiotensin-converting enzyme (ACE) I/D polymorphism and acute respiratory distress syndrome (ARDS) risk. However, the results have been inconclusive and contradictory. Therefore, we performed a meta-analysis to investigate the association between ACE I/D polymorphism and ARDS risk. METHODS: All relevant studies were searched using PubMed and EMBASE. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models or fixed-effects models. RESULTS: A total of 14 studies with 5218 subjects were included in this meta-analysis. We found that ACE I/D polymorphism significantly associated with an increased ARDS risk (OR=1.57; 95% CI 1.30-1.89; P<0.00001). In the subgroup analysis by race, Caucasians with ACE I/D polymorphism showed increased ARDS risk (OR=1.63; 95% CI 1.32-2.02; P<0.00001). However, Asians with this polymorphism did not show significantly increased ARDS risk (OR=1.31; 95% CI 0.90-1.90; P=0.95). In the subgroup analysis by age group, adults showed increased ARDS risk (OR=1.60; 95% CI 1.32-1.93; P<0.00001), while pediatric patients did not have increased ARDS risk (OR=1.15; 95% CI 0.57-2.30; P=0.70). CONCLUSIONS: This meta-analysis suggested that ACE I/D polymorphism might contribute to the susceptibility for ARDS.
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Deng et al. (2015) conducted a meta-analysis in Acute respiratory distress syndrome (ARDS) (n=5,218). ACE I/D polymorphism was evaluated on ARDS risk (OR 1.57, 95% CI 1.30-1.89, p=<0.00001). ACE I/D polymorphism was significantly associated with an increased risk of acute respiratory distress syndrome (OR 1.57; 95% CI 1.30-1.89; P<0.00001).
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