Key result
ACE gene I/D polymorphism linked to ~29% greater allergic rhinitis risk, except in East Asians.
Why the study?
Angiotensin-converting enzyme (ACE) gene I/D polymorphism might be linked to the risk of allergic rhinitis (AR), but the association required clarification.
Is Angiotensin-converting enzyme (ACE) gene I/D polymorphism associated with susceptibility to allergic rhinitis?
Meta-Analysis (n=1,164)
Is Angiotensin-converting enzyme (ACE) gene I/D polymorphism associated with susceptibility to allergic rhinitis?
Odds Ratio: 1.29 (95% CI 1.08–1.54)
p-value: p=0.005
ACE gene I/D polymorphisms may be associated with overall allergic rhinitis risk, but this association is not present in East Asian populations.
Should not influence cardiovascular prescribing decisions for patients with allergic rhinitis; leaves open whether ACE genotype modifies broader.
BACKGROUND: Angiotensin-converting enzyme (ACE) gene I/D polymorphism might be linked to the risk of the allergic rhinitis (AR). OBJECTIVE: In the present study, we assessed the association of ACE gene I/D polymorphisms with AR susceptibility using a meta-analysis. MATERIALS AND METHODS: We carried out a retrieval of studies and included the eligible studies if they met the criteria. After the data extraction, the Stata software was used to analyse the genotype frequencies. RESULTS: In total, five studies with 561 patients and 603 controls were included. However, the genotype distribution among the control of one study was not consistent with the Hardy-Weinberg equilibrium. After pooling all studies, the results indicated an association between ACE gene I/D polymorphism and AR risk in the overall analysis (II vs. others: OR=0.70, 95% CI=0.54-0.92, P=0.010; D vs. I: OR=1.29, 95% CI=1.08-1.54, P=0.005). In the further analysis of the East Asians, no association between ACE gene I/D polymorphism and AR risk was observed. CONCLUSION: ACE gene I/D polymorphisms were not associated with the risk of AR in East Asians. These results need to be confirmed in the following studies.
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Guo et al. (2014) conducted a meta-analysis in Allergic rhinitis (n=1,164). ACE gene I/D polymorphism (D allele) vs. I allele was evaluated on Allergic rhinitis risk (OR 1.29, 95% CI 1.08-1.54, p=0.005). ACE gene I/D polymorphism was associated with an increased risk of allergic rhinitis overall (D vs. I: OR 1.29; 95% CI 1.08-1.54; P=0.005), though this association was not observed in East Asians.
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