Key result
The ACE I/D polymorphism was significantly associated with an elevated risk of pediatric asthma, with the D allele increasing risk compared to the I allele (OR 1.87).
Why the study?
The correlation between the angiotensin-converting enzyme insertion/deletion polymorphism and pediatric asthma risk required assessment.
Does the ACE I/D polymorphism increase susceptibility to pediatric asthma?
Meta-Analysis (n=1,434)
Does the ACE I/D polymorphism increase susceptibility to pediatric asthma?
Odds Ratio: 1.87 (95% CI 1.59–2.2)
The ACE I/D polymorphism, particularly the D allele, is significantly associated with an increased risk of pediatric asthma, especially in Asian populations.
Supports ACE I/D genotyping for pediatric asthma risk stratification; leaves open causal validation and prospective trials.
Objective: The correlation of the angiotensin-converting enzyme ( ACE) insertion/deletion (I/D) polymorphism with pediatric asthma risk was assessed in this meta-analysis. Methods: PubMed, Web of Science, Embase and CNKI databases were systematically searched for relevant literature, followed by application of odds ratios (OR) along with 95% confidence interval (CI) for determining the strength of relationship. Results: Seven articles with 802 cases and 632 controls fulfilled the inclusion criteria. As a result, the ACE I/D polymorphism was related to elevated pediatric asthma risk (D vs I: OR = 1.87, 95% CI = 1.59–2.20; dominant model: OR =1.53, 95% CI = 1.28–1.81; recessive model: OR =1.54, 95% CI = 1.28–1.85; DD vs II: OR =2.95, 95% CI = 2.19–3.98; DI vs II: OR = 0.96, 95% CI = 0.78–1.19). Subgroup analysis stratified by race revealed significant interrelation in Asians. Conclusion: This meta-analysis demonstrated that the ACE I/D polymorphism might be related to the risk of pediatric asthma.
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Shao et al. (2020) conducted a meta-analysis in Pediatric asthma (n=1,434). ACE I/D polymorphism (D allele) vs. I allele was evaluated on Pediatric asthma risk (OR 1.87, 95% CI 1.59-2.20). The ACE I/D polymorphism was significantly associated with an elevated risk of pediatric asthma, with the D allele increasing risk compared to the I allele (OR 1.87).
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