Key result
The ACE gene D/D genotype was significantly more prevalent in preterm neonates with respiratory distress syndrome compared to controls (48.3% vs 20%, P<0.001).
Why the study?
Is angiotensin-converting enzyme (ACE) gene polymorphism associated with respiratory distress syndrome in preterm neonates?
Case-Control (n=240)
Is angiotensin-converting enzyme (ACE) gene polymorphism associated with respiratory distress syndrome in preterm neonates?
Absolute Event Rate: 48.3% vs 20%
p-value: p=<0.001
The D/D genotype of the ACE gene is associated with an increased risk of respiratory distress syndrome and bronchopulmonary dysplasia in preterm neonates.
OBJECTIVE: The aim of this study was to investigate the possible relationship between angiotensin-converting enzyme (ACE) gene polymorphism (D/D and I/D genotypes) and respiratory distress syndrome (RDS) in preterm neonates. STUDY DESIGN: Our study included 120 preterm neonates (<37 weeks of gestation) with RDS (the patient group) and 120 preterm neonates without RDS (the control group). Blood samples were obtained from patients and control groups, and ACE gene polymorphism was analysed using the polymerase chain reaction method. RESULTS: D/D genotype was highly significant in the patient group compared with the control group (48.3% of RDS group vs 20% of the control group, P < 0.001). Meanwhile, I/D and I/I genotypes were significantly higher in the control group (75% and 5% of the control group vs 50% and 1.7% of the patient group, P < 0.001). D/D genotype was highly significant in neonates with bronchopulmonary dysplasia (BPD) compared with I/D genotype (P = 0.001). CONCLUSION: Our results may suggest that D/D genotype is associated with increased risk of RDS and BPD development in preterm neonates.
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Hussein et al. (2014) conducted a case-control in Respiratory distress syndrome (n=240). ACE gene D/D genotype vs. ACE gene I/D and I/I genotypes was evaluated on Presence of ACE gene D/D genotype (p=<0.001). The ACE gene D/D genotype was significantly more prevalent in preterm neonates with respiratory distress syndrome compared to controls (48.3% vs 20%, P<0.001).
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