Key result
An enriched environment improved 4-week post-myocardial infarction survival to 72% compared to 52% in standard housing and ameliorated adverse ventricular remodeling by enhancing cardiac macrophage survival.
Why the study?
Whether an enriched environment affects macrophage phenotype and function to improve postinfarction cardiac repair was unknown.
Does an enriched environment improve postinfarction cardiac repair and survival in a mouse model of myocardial infarction?
Does an enriched environment improve postinfarction cardiac repair and survival in a mouse model of myocardial infarction?
Absolute Event Rate: 72% vs 52%
Absolute Risk Reduction: 20%
p-value: p=<0.05
Environmental eustress improves post-MI cardiac repair and survival in mice by enhancing BDNF-mediated survival of reparative macrophages.
Should not yet change post-MI care; leaves open whether enriched environments improve human cardiac repair.
Macrophages play a vital role in cardiac repair following myocardial infarction (MI). An enriched environment (EE) is involved in the regulation of macrophage-related activities and disease progression; however, whether EE affects the phenotype and function of macrophages to improve postinfarction cardiac repair remains unknown. In this study, we found that EE improved cardiac function, decreased mortality, and ameliorated adverse ventricular remodeling in mice after MI, with these outcomes closely related to the increased survival of Ly6C low macrophages and their CCR2 − MHCII low subsets. EE increased the expression of brain-derived neurotrophic factor (BDNF) in the hypothalamus, leading to higher circulating levels of BDNF, which, in turn, regulated the cardiac macrophages. BDNF bound to tropomyosin receptor kinase B to activate downstream ERK1/2 and AKT pathways, promoting macrophage survival. These findings demonstrate that EE optimizes postinfarction cardiac repair and highlights the significance of EE as a previously unidentified strategy for impeding adverse ventricular remodeling.
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Bai et al. (2022) studied Myocardial Infarction. Enriched environment (EE) vs. Standard environment (SE) was evaluated on Survival rate at 4 weeks post-MI (p=<0.05). An enriched environment improved 4-week post-myocardial infarction survival to 72% compared to 52% in standard housing and ameliorated adverse ventricular remodeling by enhancing cardiac macrophage survival.
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