Why the study?
Macrophages are critical for post-MI wound healing, but the contribution of Lgr4 to macrophage phenotype and function in MI remained unclear.
Does macrophage-specific Lgr4 knockout improve post-infarction cardiac repair in a mouse model of myocardial infarction?
Population
Mice subjected to MI
Comparison
Macrophage-specific Lgr4 knockout vs controls
Design
Preclinical animal study
Authors
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Macrophage Lgr4 targeting may limit post-MI inflammation in mice; hypothesis-generating for macrophage modulation, with clinical translation remaining open.
Does macrophage-specific Lgr4 knockout improve post-infarction cardiac repair in a mouse model of myocardial infarction?
Macrophage-specific Lgr4 knockout improves post-infarction cardiac repair by attenuating the pro-inflammatory macrophage phenotype via regulation of AP-1 activity.
Huang et al. (2020) studied this question.
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