Key result
Type 2 diabetes mellitus was associated with significantly higher P-wave dispersion (200.0 ms vs 177.1 ms, p<0.05) compared to healthy relatives.
Why the study?
Does type 2 diabetes mellitus increase P-wave indices (markers of atrial conduction heterogeneity) in patients without structural heart disease compared to healthy controls?
Case-Control (n=158)
No
Does type 2 diabetes mellitus increase P-wave indices (markers of atrial conduction heterogeneity) in patients without structural heart disease compared to healthy controls?
Absolute Event Rate: 200% vs 177.1%
p-value: p=<0.05
Type 2 diabetes mellitus is associated with prolonged P-wave indices and dispersion, suggesting an increased risk for atrial conduction heterogeneity and potential atrial fibrillation even in the absence of structural heart disease.
Background: Diabetes mellitus has a negative impact on the cardiovascular system; P-wave indices were considered to reflect the discontinuous and inhomogeneous propagation of sinus impulses and prolongation of atrial conduction time. Objectives: to know importance of P-wave indices and significant of its use for prediction and evaluation of diabetic complication in type 2 diabetics. Methods and Results: A case control study, Dec. 2011, on diabetics (n=88) and healthy relatives (n= 70) were conducted in the NDC. Comparing both groups for age, sex, resting heart rate and BMI revealed insignificant differences, P > 0.05. P-wave indices of diabetics shown absence of any correlation with the age, duration of diabetes, FPG, BMI, resting heart rate and HDL; But, it shown weak correlation with HbA1c, Serum cholesterol, serum triglycerides and LDL. P-wave indices show significant higher values in diabetics than in healthy subjects, P < 0.05, except for the P min , P > 0.05. Conclusions: P-wave indices (P mean , P max , and Pd) were significantly higher in diabetics than the healthy individuals. P-wave indices of diabetics have no effect on gender, age and BMI; but, have weak correlation with HbA1c, Serum cholesterol, serum triglycerides and LDL.
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AL-Auqbi et al. (2012) conducted a case-control in Type 2 Diabetes Mellitus (n=158). Type 2 Diabetes Mellitus vs. Healthy relatives was evaluated on P-wave dispersion (Pd) (p=<0.05). Type 2 diabetes mellitus was associated with significantly higher P-wave dispersion (200.0 ms vs 177.1 ms, p<0.05) compared to healthy relatives.
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