Key result
Automated patch clamp platforms have been developed to improve the throughput and broaden the applications of electrophysiological assessment in ion channel drug discovery.
Why the study?
Electrophysiological assessment of ion channel activity is technically challenging and has been a bottleneck in discovering drugs that modulate channel function.
Provides an overview of automated patch clamp platforms and high-throughput electrophysiology in drug discovery.
Supports broader ion channel screening in discovery; leaves open validation for cardiovascular applications.
Due to their important physiological functions, ion channels are key therapeutic targets for a variety of disorders. However, electrophysiological assessment of ion channel activity is technically challenging and has been a bottleneck in the discovery of drugs that modulate channel function. To address this issue, automated patch clamp platforms have been developed with improved throughput and broader applications. An overview of the current status of high-throughput electrophysiology and its applications in drug discovery is provided.
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Liu et al. (2019) conducted a review in Ion channel disorders. High-throughput electrophysiology was evaluated. Automated patch clamp platforms have been developed to improve the throughput and broaden the applications of electrophysiological assessment in ion channel drug discovery.
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