Key result
Serum levels of adiponectin and matrix metalloproteinase-9 were significantly higher in patients with coronary heart disease compared to controls (P<0.01), suggesting plaque instability.
Why the study?
Are levels of adiponectin and MMP-9 associated with the stability of coronary heart disease?
Observational (n=226)
No
Are levels of adiponectin and MMP-9 associated with the stability of coronary heart disease?
Increased levels of adiponectin and MMP-9 are associated with coronary heart disease and suggest instability of atherosclerotic plaques.
OBJECTIVE: To analyze the changes of adiponection (ANP) and matrix metalloproteinase-9 (MMP-9) in patients with coronary heart diseases (CHD) of different types, to investigate the correlation between these changes and stability of coronary artery plague. METHODS: Inpatients of our hospital were divided into 56 cases with acute myocardial infarction (AMI), 56 cases with unstable angina pectoris (UA), 54 cases with stable angina pectoris (SA), and 60 cases with CHD excluded by using coronary arteriongraphy as the control group. Changes of ANP and MMP-9 were determined, and the correlation was analyzed. RESULTS: 1. ANP and MMP-9 levels in CHD group were higher than those of control group (P < 0.01). 2. Serum ANP and MMP-9 levels in AMI and UA groups were significantly higher than those in control group and SA group (P < 0.05). 3. MMP-9 level in AMI group was significantly higher than that in UA group (P < 0.01). CONCLUSION: 1. Increased ANP and MMP-9 levels are the independent risk factors of CHD; 2. Increased levels of ANP and MMP-9 in patients with CHD suggest instability of atherosclerotic plaque.
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Ya Li (2015) conducted an observational in Coronary heart disease (n=226). Adiponectin (ANP) and matrix metalloproteinase-9 (MMP-9) levels vs. Control group (CHD excluded by coronary arteriography) was evaluated on Serum levels of ANP and MMP-9 (p=<0.01). Serum levels of adiponectin and matrix metalloproteinase-9 were significantly higher in patients with coronary heart disease compared to controls (P<0.01), suggesting plaque instability.
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