Key result
Serum MMP-9 levels were higher in ACS patients than in those with stable angina, with a cutoff of 3100 pg/mL discriminating MI from unstable angina and 4700 pg/mL predicting poor outcomes.
Why the study?
Does serum MMP-9 level discriminate myocardial infarction from unstable angina and predict poor outcomes in patients with acute coronary syndrome?
Observational (n=120)
Does serum MMP-9 level discriminate myocardial infarction from unstable angina and predict poor outcomes in patients with acute coronary syndrome?
Serum MMP-9 may serve as a useful biomarker to differentiate myocardial infarction from unstable angina and predict adverse clinical outcomes in patients with acute coronary syndrome.
May aid MI discrimination and outcome prediction in ACS; hypothesis-generating and requires prospective validation before clinical use.
We measured levels of matrix metalloproteinase 9 (MMP-9) as a potential risk factor in 75 patients with acute coronary syndrome (ACS) compared to 25 patients with stable angina (SA) and 20 healthy participants. Patients were studied stressing on smoking, hypertension, diabetes, lipid profile, cardiac enzymes, MMP-9, and electrocardiography. Patients with ACS had higher MMP-9 levels than the SA group. The highest MMP-9 levels were found among ST-elevated myocardial infarction (MI), while the lowest levels were found among the control group. The MMP-9 level was significantly higher among patients with ACS having poor disease outcome (recurrent ischemic attacks, congestive heart failure, or death). The MMP-9 cutoff value of 3100 pg/mL was able to discriminate MI from unstable angina (UA), while the best prognostic utility was established at 4700 pg/mL. We suggest that serum MMP-9 could be an early marker that discriminates MI from UA and predicts poor outcome in terms of disease severity and extent of disease complications.
No takes yet. Share an insight, caveat, or question.
Hamed et al. (2015) conducted an observational in Acute Coronary Syndrome (n=120). Matrix metalloproteinase 9 (MMP-9) levels vs. Stable angina and healthy participants was evaluated on MMP-9 levels and their association with disease severity and outcomes. Serum MMP-9 levels were higher in ACS patients than in those with stable angina, with a cutoff of 3100 pg/mL discriminating MI from unstable angina and 4700 pg/mL predicting poor outcomes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: