Why the study?
Is the elevated circulating plasma MMP-9 in patients with acute myocardial infarction originating from the culprit coronary artery plaque?
Population
33 patients undergoing percutaneous coronary intervention, comprising 23 with acute myocardial infarction…
Comparison
Blood sampling from the femoral artery and… vs Patients with stable angina pectoris undergoing…
Design
Cross-sectional
Authors
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Supports local coronary MMP-9 release in AMI; leaves open causal role in rupture or biomarker utility.
Is the elevated circulating plasma MMP-9 in patients with acute myocardial infarction originating from the culprit coronary artery plaque?
MMP-9 is primarily released into the coronary circulation directly from the culprit coronary artery plaque in patients with acute myocardial infarction.
Higo et al. (2005) studied this question.
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