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February 1, 1997AJP Cell Physiology

Downregulation of volume-activated Cl- currents during muscle differentiation

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Population

BC3H1 and C2C12 mouse muscle cell lines

Comparison

Reduction in extracellular osmolality by 40% and… vs Proliferating versus differentiated state

Design

Preclinical

Authors

TVThomas VoetsVIB-KU Leuven Center for MicrobiologyLWLin WeiSir Run Run Shaw HospitalPSPatrick De SmetUniversity of Siena

Discussion

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Overview

May indicate Cl- current role in myogenesis; leaves open relevance to human muscle disease or therapy.

Structured PICO

P
Population
BC3H1 and C2C12 mouse muscle cell lines
I
Intervention
Reduction in extracellular osmolality by 40% and reduction in serum concentration to induce differentiation
C
Comparator
Proliferating versus differentiated state
O
Outcome
Magnitude of volume-activated Cl- currentssurrogate

Volume-activated Cl- currents are downregulated during muscle cell differentiation, suggesting a potential role in cell proliferation.

Cite This Study

Voets et al. (1997) studied this question.

synapsesocial.com/papers/6a844a5ba47fb2e1cdb2a075https://doi.org/10.1152/ajpcell.1997.272.2.c667
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Permeation properties and modulation of volume‐activated Cl−‐currents in human endothelial cells1994 · 68 citations
  2. 2Developmental expression of voltage‐sensitive K<sup>+</sup> channels in mouse skeletal muscle and C<sub>2</sub>C<sub>12</sub> cells1992 · 51 citations
  3. 3Transport of organic substrates via a volume-activated channel.1992 · 161 citations
  4. 4Isoform switching of the sarco(endo)plasmic reticulum Ca2+ pump during differentiation of BC3H1 myoblasts.1991 · 46 citations
  5. 5A voltage‐gated chloride channel in ascidian embryos modulated by both the cell cycle clock and cell volume.1995 · 46 citations