Population
Interstitial cells of Cajal (ICC) cultured through the explant technique
Design
Preclinical
Authors
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Animal findings link ICC volume sensing to excitability; hypothesis-generating for GI motility mechanisms with no current clinical implications.
Swelling or volume change depolarizes interstitial cells of Cajal through activation of outwardly rectifying chloride channels, thereby increasing cell excitability.
Park et al. (2005) studied this question.
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