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November 22, 1983Proceedings of the Royal Society B Biological Sciences

Voltage-operated channels induced by foreign messenger RNA in Xenopus oocytes

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Population

Xenopus laevis oocytes

Design

Preclinical

Authors

CGCameron B. GundersenUniversity of California, Los AngelesRMRicardo MilediAustralian National UniversityIPIan ParkerUniversity of California, Irvine

Discussion

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Implication

Enables functional studies of cardiac ion channels in oocytes; leaves open translation to mammalian or clinical models without further validation.

Structured PICO

P
Population
Xenopus laevis oocytes
I
Intervention
Injection of Poly(A)+ messenger RNA (mRNA) extracted from rat brains or cat muscles
O
Outcome
Incorporation of voltage-operated Na+ and K+ channels into the oocyte membranesurrogate

Foreign mRNA injected into Xenopus oocytes can be translated and processed to form functional voltage-operated ion channels in the cell membrane.

Cite This Study

Gundersen et al. (1983) studied this question.

synapsesocial.com/papers/6a844a5dc2c8a33f31f7a4d7https://doi.org/10.1098/rspb.1983.0092
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sodium currents in mammalian muscle1977 · 110 citations
  2. 2Glutamate and kainate receptors induced by rat brain messenger RNA in Xenopus oocytes1984 · 109 citations
  3. 3Ionic currents in slow twitch skeletal muscle in the rat.1980 · 47 citations
  4. 4Comparison between the delayed outward current in slow and fast twitch skeletal muscle in the rat.1980 · 51 citations
  5. 5Recording of single γ-aminobutyrate- and acetylcholine-activated receptor channels translated by exogenous mRNA in Xenopus oocytes1983 · 45 citations