Key result
Injection of rat atrial RNA into Xenopus oocytes resulted in the expression of a G-protein-activated K+ channel that could be activated by acetylcholine or serotonin.
Rat atrial RNA directs the expression of a functional G-protein-activated inwardly rectifying K+ channel in Xenopus oocytes, providing a model for future molecular cloning and coupling studies.
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Enables molecular dissection of cardiac G-protein K+ channels; leaves open any role in human arrhythmias or therapy.
Dascal et al. (1993) studied this question. Injection of rat atrial RNA and 5HT1A receptor RNA vs. Native oocytes or oocytes injected with 5HT1A-R RNA alone was evaluated on Expression of a G-protein-activated K+ channel (I5HT current). Injection of rat atrial RNA into Xenopus oocytes resulted in the expression of a G-protein-activated K+ channel that could be activated by acetylcholine or serotonin.
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