In frog atrial muscle, manganese chloride decreases the outward background current without altering the delayed outward current, likely reflecting a decrease in IK1 and Na-Ca exchange current.
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These amphibian findings warrant no change in clinical electrophysiology practice; leaves open further exploration of manganese as a selective current modulator in mammalian models.
The effects of MnCl2 on outward currents in frog atrial muscle were investigated under voltage-clamp conditions. MnCl2 (3 mmol/L), which completely abolished the slow inward current, produced a decrease in the outward background current (Ib) at potentials positive to -50 mV. The delayed outward current (Ix, time dependent) was not altered by Mn. "Isochronic activation curves" for Ix and decay of current tails at -40 mV remained unaffected after Mn. Effects on Ib probably reflect a decrease in IK1 related to the decrease in Ca influx as well as a reduction in the Na-Ca exchange current.
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Álvarez et al. (1985) studied this question.
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