Internal Mg2+ modulates the delayed rectifier potassium current in frog atrial myocytes, potentially via a Mg2+-dependent phosphatase mechanism, while isoprenaline increases the current independently of Mg2+ concentration.
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Animal data on Mg2+ block of IK warrant no clinical extrapolation; leaves open mechanism and relevance in mammalian models.
Duchatelle‐Gourdon et al. (1991) studied this question.
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