Key result
An increase in free intracellular Mg2+ concentration led to a dose-dependent decrease in the delayed rectifier K+ current (I(K)) with a half-maximal effect of approximately 20 nM.
Why the study?
Does increased intracellular Mg2+ alter the delayed rectifier K+ current in guinea pig ventricular myocytes?
Population
Guinea pig ventricular myocytes
Comparison
Increase in free intracellular Mg2+ concentration vs Control (lower or baseline [Mg2+]i)
Design
Preclinical
Authors
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Should not change clinical Mg2+ use; leaves open whether intracellular magnesium modulates repolarization in human hearts.
Does increased intracellular Mg2+ alter the delayed rectifier K+ current in guinea pig ventricular myocytes?
Intracellular magnesium dose-dependently decreases the delayed rectifier K+ current and shifts its activation to more positive voltages in guinea pig ventricular myocytes, likely independent of protein phosphatase activity.
Williams et al. (1997) studied this question. Intracellular Mg2+ vs. Control was evaluated on Delayed rectifier K+ current (I(K)). An increase in free intracellular Mg2+ concentration led to a dose-dependent decrease in the delayed rectifier K+ current (I(K)) with a half-maximal effect of approximately 20 nM.
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