June 1, 1995AJP Heart and Circulatory Physiology

Dual effects of external magnesium on action potential duration in guinea pig ventricular myocytes

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Population

Guinea pig ventricular myocytes

Comparison

Extracellular magnesium at varying… vs Baseline or lower concentrations of Mg2+

Design

Preclinical

Authors

SZShetuan ZhangQueen's University TST SawanoboriTokyo Medical and Dental University HAHitoshi AdaniyaTokyo Medical and Dental University

Discussion

Member takes

Implication

Caution against clinical magnesium dosing changes; leaves open translation of concentration-dependent APD effects to human myocardium.

Structured PICO

Population

Guinea pig ventricular myocytes

Intervention

Extracellular magnesium (Mg2+) at varying concentrations (0.5 to 10 mM) and manganese (1-5 mM)

Comparator

Baseline or lower concentrations of Mg2+ (e.g., 0.5 mM)

Outcome

Action potential duration at 90% repolarization (APD90) and underlying membrane currents (K+ and Ca2+ currents)surrogate

Extracellular magnesium exerts dual, concentration-dependent effects on action potential duration in guinea pig ventricular myocytes by modulating calcium and potassium currents.

Cite This Study

Zhang et al. (1995) studied this question.

synapsesocial.com/papers/6a7cdbfeccf86f44befebf2e https://doi.org/10.1152/ajpheart.1995.268.6.h2321

View Full Paper

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Dual effects of external magnesium on action potential duration in guinea pig ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dual effects of external magnesium on action potential duration in guinea pig ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider