June 1, 1975Circulation Research

Depolarization-induced movement of Mn 2 cations across the cell membrane in the guinea pig myocardium.

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Population

Guinea pig ventricular strips

Comparison

Mn2+-containing solutions (10 mM) vs Quiescent preparations or Ca2+-depleted…

Design

Preclinical

Authors

JDJ DelahayesCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

Alerts to Mn2+ interference with myocardial function in research models; leaves open human cardiac relevance pending translational studies.

Structured PICO

Population

Guinea pig ventricular strips

Intervention

Mn2+-containing solutions (10 mM)

Comparator

Quiescent preparations or Ca2+-depleted preparations

Outcome

Mechanical and electrical responses (twitch responses, contracture, action potential duration, dV/dt-max, Mn2+ uptake)surrogate

Mn2+ generates a transmembrane current and interferes with excitation-contraction coupling at the cell membrane and intracellularly in guinea pig myocardial cells.

Cite This Study

J Delahayes (1975) studied this question.

synapsesocial.com/papers/6a732453c031cbaf3c153ecd https://doi.org/10.1161/01.res.36.6.713

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Implication

Alerts to Mn2+ interference with myocardial function in research models; leaves open human cardiac relevance pending translational studies.

Depolarization-induced movement of Mn 2 cations across the cell membrane in the guinea pig myocardium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Depolarization-induced movement of Mn 2 cations across the cell membrane in the guinea pig myocardium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider