Key result
In guinea-pig myocardium perfused by sodium-free media, manganese passes through the slow inward current channel to generate action potentials, with overshoots increasing by 20-30 mV per tenfold Mn increase.
Manganese can pass through the slow inward current channel to generate action potentials in guinea-pig myocardium under sodium-free conditions.
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Mn supports overshooting action potentials in isolated muscle; leaves open physiological roles for divalent cations in vivo.
Rikuo Ochi (1976) studied Guinea-pig myocardium. Manganese in sodium-free media was evaluated on Propagated action potentials (overshoot and resting potential). In guinea-pig myocardium perfused by sodium-free media, manganese passes through the slow inward current channel to generate action potentials, with overshoots increasing by 20-30 mV per tenfold Mn increase.
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