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November 16, 2004Cardiovascular Research

Modulation of the voltage-dependent K current by intracellular Mg in rat aortic smooth muscle cells

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Population

Single rat aortic myocytes isolated from adult Wistar rat thoracic aorta and endothelium-denuded rat aortic…

Design

Preclinical

Authors

PTPaolo TammaroUniversity of OxfordASAustin T. SmithIntermountain HealthcareBCBrendan M. CrowleyUnited States Military Academy

Discussion

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Overview

Hypothesis-generating for Mg2+ effects on vascular K+ channels in animals; leaves open relevance to human vasomotor function or disease.

Structured PICO

P
Population
Single rat aortic myocytes (RAMs) isolated from adult Wistar rat thoracic aorta and endothelium-denuded rat aortic rings
I
Intervention
Intracellular magnesium ions (Mg2+i) / Mg2+ loading
O
Outcome
Voltage-gated K+ (KV) currents (IKv) and vascular reactivitysurrogate

Intracellular magnesium modulates voltage-gated K+ channels in vascular smooth muscle cells, providing a novel mechanism for regulating vascular excitability.

Cite This Study

Tammaro et al. (2004) studied this question.

synapsesocial.com/papers/6a70bc3ba2d7cf2e39c2b540https://doi.org/10.1016/j.cardiores.2004.10.035
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrophysiologically distinct smooth muscle cell subtypes in rat conduit and resistance pulmonary arteries2002 · 66 citations
  2. 2Internal Na+ and Mg2+ blockade of DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes. Inward rectification of a delayed rectifier.1994 · 42 citations
  3. 3Cellular mechanisms of vasopressin and endothelin to mobilize [Mg2+]i in vascular smooth muscle cells1992 · 27 citations
  4. 4Abnormal magnesium status in patients with cardiovascular diseases2000 · 35 citations