What question did this study set out to answer?

To assess associations between serum interleukin-10 concentrations and demographic factors, inflammatory markers, organ involvement, disease activity, and treatment response in patients with systemic lupus erythematosus.

April 2, 2025International Journal of Molecular SciencesOpen Access

IL-10 in Systemic Lupus Erythematosus: Balancing Immunoregulation and Autoimmunity

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Authors

PRPatricia RichterClinical Emergency Hospital Bucharest LMLuana Andreea MacoveiClinical Emergency Hospital Bucharest CRCiprian RezușGrigore T. Popa University of Medicine and Pharmacy

Discussion

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Implication

Observational study finds serum interleukin-10 correlates with inflammatory markers and autoantibodies in lupus patients, indicating immune involvement independent of disease activity.

Key Points

To assess associations between serum interleukin-10 concentrations and demographic factors, inflammatory markers, organ involvement, disease activity, and treatment response in patients with systemic lupus erythematosus.
Enrolled 88 patients with systemic lupus erythematosus at a single rheumatology clinic in Iași, Romania.
Assessed disease activity via the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and measured serum cytokine levels using enzyme-linked immunosorbent assay (ELISA).
Serum IL-10 levels were significantly higher in males than in females (47.62 pg/mL vs. 13.24 pg/mL, p = 0.011), with no significant association with age or disease duration.
IL-10 positively correlated with inflammatory markers and autoantibodies, including C-reactive protein (p = 0.002), IL-6 (p = 0.01), ANA (p = 0.014), and anti-SSB antibodies (p = 0.005).
No statistically significant correlations were observed between IL-10 levels and SLEDAI score, specific organ manifestations, or treatment response.

Cite This Study

Richter et al. (2025) studied this question.

synapsesocial.com/papers/6a844e1c31983d826d0bb2f8 https://doi.org/10.3390/ijms26073290

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Implication

Observational study finds serum interleukin-10 correlates with inflammatory markers and autoantibodies in lupus patients, indicating immune involvement independent of disease activity.

IL-10 in Systemic Lupus Erythematosus: Balancing Immunoregulation and Autoimmunity

Discussion

Member takes

Implication

Key Points

Cite This Study

IL-10 in Systemic Lupus Erythematosus: Balancing Immunoregulation and Autoimmunity

Discussion

Member takes

Implication

Key Points

Cite This Study

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