Why the study?
Does dissociation between ventilation and chemical drive induce breathlessness in normal subjects?
Population
10 naive normal subjects
Comparison
Adjusting ventilation to five different levels… vs Chemically driven ventilation at PETCO2 = 55 mm Hg
Design
Other
Authors
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Breathlessness may arise from ventilatory suppression below chemical drive in healthy subjects; leaves open its role in clinical dyspnea.
Does dissociation between ventilation and chemical drive induce breathlessness in normal subjects?
Suppressed ventilation below chemically driven levels induces breathlessness, suggesting that dissociation between chemical drive and afferent signals from lung/chest wall motion modulates this sensation.
Schwartzstein et al. (1989) studied this question.
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