Key result
In adolescents with type 1 diabetes and a high night-to-day blood pressure ratio, hyperglycemia and Angiotensin II infusion resulted in significant increases in GFR and filtration fraction.
Why the study?
Do renal hemodynamic responses to hyperglycemia, angiotensin II, and ACE inhibition differ in adolescents with type 1 diabetes based on their diurnal blood pressure ratio?
Population
Adolescents with uncomplicated type 1 diabetes, segregated into two groups based on the presence or absence…
Comparison
Experiment 1: euglycemia and hyperglycemia… vs Normal N/D BP ratio group vs high N/D ratio…
Design
Other
Follow-up
3 weeks (for ACE inhibition experiment)
Authors
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Diurnal BP ratio may stratify renal hemodynamic risk in T1D adolescents; leaves open whether targeting these responses improves outcomes.
Do renal hemodynamic responses to hyperglycemia, angiotensin II, and ACE inhibition differ in adolescents with type 1 diabetes based on their diurnal blood pressure ratio?
In adolescents with type 1 diabetes and abnormal diurnal blood pressure, deleterious renal hemodynamic responses to high glucose and Ang II, along with insensitivity of hyperfiltration to ACE inhibition, may explain adverse renal outcomes.
Miller et al. (2003) studied Type 1 diabetes. Hyperglycemia, Angiotensin II infusion, and ACE inhibition vs. Euglycemia and baseline state was evaluated on Renal hemodynamic responses (glomerular filtration rate and filtration fraction). In adolescents with type 1 diabetes and a high night-to-day blood pressure ratio, hyperglycemia and Angiotensin II infusion resulted in significant increases in GFR and filtration fraction.
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