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August 1, 1988Anesthesia & Analgesia

Cardiovascular Effects of Fentanyl Reversal by Naloxone at Varying Arterial Carbon Dioxide Tensions in Dogs

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Why the study?

Does PaCO2 level affect the hemodynamic and adrenergic responses to naloxone reversal of fentanyl in dogs?

Population

6 dogs undergoing 24 experiments under enflurane anesthesia

Comparison

Naloxone 0.4 mg for reversal of fentanyl at… vs Pre-fentanyl baseline values and comparison…

Design

Preclinical

Authors

CMC. A. MillsAustralian Regenerative Medicine InstituteJFJoan W. FlackeUniversity of California, Los AngelesJMJordan D. MillerStructural Heart Disease

Discussion

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Implication

Hypercapnia may amplify post-naloxone adrenergic surges in dogs; leaves open whether PaCO2 modulates reversal hemodynamics in patients.

Structured PICO

Does PaCO2 level affect the hemodynamic and adrenergic responses to naloxone reversal of fentanyl in dogs?

P
Population
6 dogs undergoing 24 experiments under enflurane anesthesia
I
Intervention
Naloxone 0.4 mg for reversal of fentanyl (50 micrograms/kg) at varying PaCO2 levels (20, 35, and 60 mm Hg)
C
Comparator
Pre-fentanyl baseline values and comparison between different PaCO2 levels (hypocapnic vs hypercapnic)
O
Outcome
Hemodynamic (mean arterial blood pressure, heart rate) and adrenergic (plasma norepinephrine and epinephrine) responsessurrogate

Hypercapnia exacerbates the adrenergic and hemodynamic stimulation following naloxone reversal of fentanyl in dogs.

Cite This Study

Mills et al. (1988) studied this question.

synapsesocial.com/papers/6a84505ec7e37ebe3168d437https://doi.org/10.1213/00000539-198808000-00003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Short-term effects of naloxone hemodynamics and baroreflex function in conscious dogs with pacing-induced congestive heart failure1994 · 24 citations
  2. 2Postsystolic Shortening of Canine Left Ventricle Supplied by a Stenotic Coronary Artery when Nitrous Oxide Is Added in the Presence of Narcotics1985 · 41 citations
  3. 3Fentanyl activates opposing opioid and non-opioid receptor systems that control breathing2024 · 16 citations
  4. 4Xylazine/fentanyl combinations cause severe and long-lasting respiratory suppression resistant to naloxone reversal2026
  5. 5Evaluating the rate of reversal of fentanyl-induced respiratory depression using a novel long-acting naloxone nanoparticle, cNLX-NP2024 · 10 citations