Key result
Two SNPs (rs80937718 and rs80929898 in SLA DQA1) significantly affected the humoral response to classical swine fever vaccination in Desi × Landrace piglets (P < 0.01).
Observational
p-value: p=< 0.01
Specific single nucleotide polymorphisms in the SLA DQA1 gene are associated with the humoral immune response to classical swine fever vaccination in cross-bred piglets.
SLA DQA1 SNPs were associated with CSF vaccine response in piglets; hypothesis-generating for marker-assisted selection.
In present investigation genetic variability in humoral response to classical swine fever (CSF) vaccination was explored. The aim of the study was to find association of 14 single nucleotide polymorphisms (SNPs) (IL-1β, MX1, IRF3 and SLA genes) with humoral response measured in terms of percentage inhibition of E2 antibody by competitive enzyme-linked immunosorbent assay. The post-vaccination response of CSF vaccination was low to moderate in Desi piglets ranged from 25.29% to 92.23% whereas it was moderate to high in Desi × Landrace piglets ranged from 69.30% to 100%. The response to CSF vaccination was significantly (P < 0.0001) differing in Desi and Desi × Landrace piglets. The mean percentage inhibition in Desi piglets was 62.73% but in Desi × Landrace cross-bred it was 97.24%. None of the SNPs of present investigation was significantly associated with humoral immune response in Desi piglets. Two SNPs namely rs80937718 (SLA DQA1) and rs80929898 (SLA DQA1) were significantly (P < 0.01) affecting the humoral response of CSF vaccination in Desi × Landrace piglets.
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Singh et al. (2015) conducted an observational in Classical swine fever vaccination response. Single nucleotide polymorphisms (SNPs) in IL-1β, MX1, IRF3 and SLA genes was evaluated on Humoral response measured by percentage inhibition of E2 antibody (p=< 0.01). Two SNPs (rs80937718 and rs80929898 in SLA DQA1) significantly affected the humoral response to classical swine fever vaccination in Desi × Landrace piglets (P < 0.01).
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