Key result
TGFβ signaling exhibits dual roles in myocardial infarction, acting cardioprotective in the early phase but promoting adverse remodeling, apoptosis, hypertrophy, and fibrosis in the late phase.
Design
Review
Authors
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Timed TGFβ modulation may balance MI phases; leaves open phase-specific trials before clinical use.
Therapeutic targeting of TGFβ signaling after myocardial infarction requires precise timing to prevent late adverse remodeling while preserving early cardioprotective effects.
Gerhild Euler (2015) conducted a review in Myocardial infarction. TGFβ signaling was evaluated. TGFβ signaling exhibits dual roles in myocardial infarction, acting cardioprotective in the early phase but promoting adverse remodeling, apoptosis, hypertrophy, and fibrosis in the late phase.
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