Key result
Automatic ECG extraction using Antares at optimized time points significantly reduced QTcB intervals (402 vs 414 ms, P<0.05) and heart rate compared to fixed time point extraction.
Why the study?
Does automatic ECG extraction using Antares reduce noise and improve QT interval stability compared to fixed time point extraction in healthy subjects?
Population
Healthy subjects administered with sotalol
Comparison
Automatic 12-lead ECG extraction using Antares vs ECG extractions at fixed time points
Design
Other
Authors
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Optimized ECG extraction may enhance QTc stability in Holter recordings; leaves open effects on clinical decisions or trial endpoints.
Does automatic ECG extraction using Antares reduce noise and improve QT interval stability compared to fixed time point extraction in healthy subjects?
Absolute Event Rate: 402% vs 414%
p-value: p=< 0.05
Automatic extraction of discrete 12-lead ECG strips from continuous Holter recordings using optimized time points generates less noisy and more stable ECGs, leading to more robust QTc data.
Badilini et al. (2009) studied Healthy subjects. Antares automatic 12-lead extraction (optimized time points) vs. ECG extractions at fixed time points was evaluated on Corrected QT interval (QTcB) (p=< 0.05). Automatic ECG extraction using Antares at optimized time points significantly reduced QTcB intervals (402 vs 414 ms, P<0.05) and heart rate compared to fixed time point extraction.
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