Why the study?
Does preoperative bowel preparation with PEG, Prepacol, or Ringer's lactate differ in efficacy and morbidity in patients undergoing colorectal surgery?
Does preoperative bowel preparation with PEG, Prepacol, or Ringer's lactate differ in efficacy and morbidity in patients undergoing colorectal surgery?
Polyethylene glycol (PEG) is the most suitable agent for preoperative bowel preparation in colorectal surgery, balancing efficacy with a lower risk of fluid retention and postoperative complications.
PEG preferred for colorectal surgery bowel prep; extends RCT evidence favoring its safety over alternatives without compromising cleansing.
Three different methods of preoperative bowel preparation were tested in a prospective randomized trial examining efficacy and morbidity. In all, 163 patients were treated by gut irrigation with Ringer's lactate, Prepacol or polyethylene glycol (PEG). Fluid retention, cleansing effect, postoperative complications and subjective acceptance were documented. Relevant weight gain and decrease in haematocrit indicating fluid retention were seen only after the use of Ringer's lactate. There were no significant differences in bowel cleansing. In the Prepacol group the postoperative complication rate was significantly increased. Prepacol was tolerated best, with few side-effects. PEG was better tolerated than Ringer's lactate, but vomiting occurred in 2 and 21 per cent of patients respectively. PEG is most suitable for bowel preparation in patients undergoing colorectal surgery.
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Wolters et al. (1994) studied this question.
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