Key result
Treatment of samples with DOAC-Remove successfully reversed DOAC interference in haemostasis assays (P<0.05) and prevented inappropriate detection of lupus anticoagulant in 5% of patients.
Why the study?
Despite recommendations, haemostasis testing continues in patients taking direct oral anticoagulants, prompting the evaluation of a diagnostic algorithm using DOAC-Remove to aid accuracy.
Does DOAC-Remove prevent inappropriate detection of lupus anticoagulant and reverse DOAC interference in haemostasis assays for patients taking direct oral anticoagulants?
Population
1566 routine patient samples
Comparison
Testing before vs after DOAC-Remove treatment
Design
Validation and laboratory algorithm study
Authors
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May reduce false-positive LA results in DOAC patients; leaves open prospective validation before routine adoption.
Observational (n=1,566)
Does DOAC-Remove prevent inappropriate detection of lupus anticoagulant and reverse DOAC interference in haemostasis assays for patients taking direct oral anticoagulants?
p-value: p=<0.05
DOAC-Remove effectively eliminates DOAC interference in haemostasis assays, preventing false-positive lupus anticoagulant diagnoses and improving diagnostic accuracy.
Cox‐Morton et al. (2019) conducted an observational in Patients taking direct oral anticoagulants (DOAC) (n=1,566). DOAC-Remove vs. Baseline (pre-DOAC-Remove) was evaluated on Reversal of DOAC interference on intrinsic factor assays, PT/aPTT, and APC sensitivity ratio (p=<0.05). Treatment of samples with DOAC-Remove successfully reversed DOAC interference in haemostasis assays (P<0.05) and prevented inappropriate detection of lupus anticoagulant in 5% of patients.
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