Key result
One-year treatment with atorvastatin 40 mg daily decreased the intima-media thickness of both right and left carotid arteries in patients with ischemic stroke.
Why the study?
Occlusion of the initial segment of the internal carotid artery is the most common cause of cerebral vascular events, prompting evaluation of one-year atorvastatin therapy on carotid intima-media thickness as a marker of atherosclerosis in stroke patients.
Does atorvastatin 40 mg once daily reduce carotid intima-media thickness in patients with ischemic stroke?
Does atorvastatin 40 mg once daily reduce carotid intima-media thickness in patients with ischemic stroke?
Long-term administration of high-dose atorvastatin (40 mg daily) is associated with a significant reduction in carotid artery intima-media thickness in patients with a history of ischemic stroke.
High-dose atorvastatin may reduce carotid IMT post-stroke; leaves open need for randomized confirmation.
Occlusion of the initial segment of internal carotid artery is the most common reason for vascular events in the brain. The purpose of this study was to investigate the effect of one-year treatment with atorvastatin on intima-media thickness (IMT) of carotid arteries as a measure of atherosclerosis in stroke patients. In this prospective interventional study, 44 patients with ischemic stroke were investigated. Patients were treated with atorvastatin 40 mg once a day for one year. IMT of carotid arteries was measured by extracranial Doppler ultrasonography in the distal part of the common carotid artery at the beginning of the study, at 6 months and one year of treatment with atorvastatin. The IMT of both right and left carotid arteries decreased after 6- and 12-month atorvastatin treatment. Based on the results of this study, long-term administration of atorvastatin was associated with reduction in carotid artery IMT in patients with ischemic stroke. Such a decrease in IMT may prevent subsequent stroke or cardiovascular events in these patients.
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Mojtaba Khazaei (2020) studied Ischemic stroke (n=44). Atorvastatin was evaluated on Intima-media thickness (IMT) of carotid arteries. One-year treatment with atorvastatin 40 mg daily decreased the intima-media thickness of both right and left carotid arteries in patients with ischemic stroke.
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