Key result
Low-dose pravastatin slows annual carotid IMT progression by ~48% vs no statins.
Why the study?
Does pravastatin 10 mg daily reduce the progression of carotid intima-media thickness in Japanese patients with noncardioembolic ischemic stroke?
Population
793 Japanese patients with noncardioembolic ischemic stroke
Comparison
Pravastatin 10 mg daily vs No statins (control group)
Design
RCT, randomized, parallel-group, open-label
Follow-up
5 years
Authors
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Supports low-dose pravastatin to slow carotid atherosclerosis after noncardioembolic stroke; extends statin IMT benefits to Japanese patients.
RCT (n=793)
Open-label
parallel-group
Yes
Does pravastatin 10 mg daily reduce the progression of carotid intima-media thickness in Japanese patients with noncardioembolic ischemic stroke?
Absolute Event Rate: 0.021% vs 0.04%
p-value: p=0.010
Low-dose pravastatin (10 mg daily) significantly reduces the progression of carotid intima-media thickness over 5 years in Japanese patients with noncardioembolic ischemic stroke.
Koga et al. (2017) conducted an RCT in Noncardioembolic ischemic stroke (n=793). Pravastatin vs. No statins was evaluated on IMT change of the common carotid artery for a 5-year observation period (p=0.010). Low-dose pravastatin significantly reduced the annual progression of carotid intima-media thickness at 5 years compared to no statins (0.021 vs 0.040 mm; P=0.010).
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