Why the study?
Does RT-PCR Assay 1 provide better sensitivity than Assay 2 for detecting enteroviral RNA in CSF samples from patients with acute aseptic meningitis?
Population
Cerebrospinal fluid samples from patients with acute aseptic meningitis, and spiked pooled CSF samples from…
Comparison
RT-PCR Assay 1 vs RT-PCR Assay 2
Design
Other
Authors
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Assay 1 may enhance enteroviral detection in clinical CSF; leaves open whether it improves outcomes or warrants routine adoption.
Does RT-PCR Assay 1 provide better sensitivity than Assay 2 for detecting enteroviral RNA in CSF samples from patients with acute aseptic meningitis?
A two-enzyme RT-PCR assay (Assay 1) is 10-fold more sensitive than a single-enzyme assay (Assay 2) for detecting enteroviral RNA in clinical CSF samples from patients with acute aseptic meningitis.
Casas et al. (1995) studied this question.
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