Population
Skeletal muscle fibers depleted of intrinsic myosin, troponin, and tropomyosin, reconstituted with labeled…
Comparison
Addition of troponin and extrinsic myosin heads vs Reconstituted fibers without the addition of…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open thin filament dynamics in human cardiac regulation.
EPR spectroscopy demonstrates that the tropomyosin domain is flexible and disordered in reconstituted thin filaments, with its orientation and mobility modulated by troponin and myosin.
Szczȩsna et al. (1995) studied this question.
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