Key result
This document is a journal masthead and contains no clinical study data.
Why the study?
Anticoagulation to maintain circuit patency and prevent thrombosis in critically ill patients on extracorporeal circuits is challenging, with low scientific evidence regarding optimal anticoagulants, monitoring tests, and therapeutic targets.
This review provides a practical overview of current concepts and strategies for anticoagulation in critically ill adults requiring extracorporeal circulation.
May inform anticoagulation decisions in extracorporeal support; leaves open standardization via prospective trials.
Extracorporeal circuits including renal replacement therapy, extracorporeal membrane oxygenation, and ventricular assist devices are increasingly used in critically ill patients. The need for anticoagulation to provide circuit patency and avoid thrombosis remains a challenging task for treating physicians. In the presence of overall low scientific evidence concerning the optimal anticoagulants, monitoring tests, and therapeutic target ranges, recommendations are largely expert opinions and most centers use individual "in-house" anticoagulation protocols. This review gives a practical view on current concepts of anticoagulation strategies in patients with extracorporeal assist devices.
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Buchtele et al. (2021) studied this question. This document is a journal masthead and contains no clinical study data.
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