Key result
An epicardial fat thickness of 8.5 to 10.2 mm measured by echocardiography increased the risk of adverse cardiovascular events by 4.3 times in patients with coronary heart disease after myocardial revascularization.
Why the study?
The role of epicardial adipose tissue in determining the risk of an adverse course of ischemic heart disease after myocardial revascularization was unclear.
Does epicardial adipose tissue thickness predict adverse outcomes in patients with ischemic heart disease after myocardial revascularization?
Cohort (n=217)
No
Does epicardial adipose tissue thickness predict adverse outcomes in patients with ischemic heart disease after myocardial revascularization?
Hazard Ratio: 4.3 (95% CI 1.2–15.3)
p-value: p=0.023
An epicardial adipose tissue thickness of 8.5 to 10.2 mm measured by echocardiography is a strong independent predictor of adverse cardiovascular events in patients undergoing myocardial revascularization.
May refine post-revascularization risk stratification; leaves open whether EAT measurement alters management or outcomes.
Objective To study the role of epicardial adipose tissue (EAT) in determination of risk for adverse course of ischemic heart disease (IHD) in patients after myocardial revascularization.Materials and Methods This study included 217 subjects, 182 IHD patients and 35 evaluated individuals without IHD. Percutaneous coronary intervention (PCI) was performed for 104 patients and coronary bypass (CB) was performed for 78 patients. Also echocardiography (EchoCG) and cardiac computed tomography were performed.Results In IHD patients, EAT volume and thickness were greater than in evaluated subjects without IHD. The composite endpoint (CEP) was observed after PCI more frequently than after CB. In IHD patients with an EAT thickness of 8.5 to 10.2 mm measured with EchoCG in the atrioventricular groove, the risk of CEP was 4.3 times higher after myocardial revascularization than with thicker or thinner EAT regardless of the revascularization method.Conclusion An EAT thickness of 8.5 to 10.2 mm in the atrioventricular groove as measured with EchoCG was associated with a risk of adverse IHD course in patients who have underwent myocardial revascularization.
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Polyakova et al. (2020) conducted a cohort in Coronary heart disease after myocardial revascularization (n=217). Epicardial fat thickness of 8.5 to 10.2 mm vs. Epicardial fat thickness <8.5 mm or >10.2 mm was evaluated on Combined clinical endpoint (death, cardiovascular events, revascularization, recurrent angina, heart failure hospitalization) (HR 4.3, 95% CI 1.2-15.3, p=0.023). An epicardial fat thickness of 8.5 to 10.2 mm measured by echocardiography increased the risk of adverse cardiovascular events by 4.3 times in patients with coronary heart disease after myocardial revascularization.
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