What question did this study set out to answer?

To evaluate the relative effects of discontinuing antithyroid drug therapy versus subsequent radioiodine (131I) ablation on thyroid hormone levels in patients with Graves disease.

October 15, 1994Annals of Internal Medicine

Discontinuing Antithyroid Drug Therapy before Ablation with Radioiodine in Graves Disease

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To evaluate the relative effects of discontinuing antithyroid drug therapy versus subsequent radioiodine (131I) ablation on thyroid hormone levels in patients with Graves disease.
Prospective clinical trial of 21 patients with hyperthyroid Graves disease scheduled for radioiodine ablation (17 pretreated with antithyroid drugs and 4 untreated controls) at a tertiary outpatient clinic.
Antithyroid medications were discontinued 6 days before radioiodine therapy, with free and total T4 and T3 levels monitored across 11 time points from day -6 to day 14.
Discontinuing antithyroid therapy caused a pre-ablation mean increase of 86% (95% CI, 16.1% to 156%) in free T4 and 71.6% (95% CI, 31% to 112%) in free T3 relative to baseline.
Following radioiodine therapy, pretreated patients showed a mean decrease in free T3 of 28.7% (95% CI, -44.1% to -13.2%) and total T3 of 22.9% (95% CI, -39.4% to -6.4%), with stable free and total T4 levels.
Untreated patients exhibited a mean reduction in free T4 of 39.8% (95% CI, -69.9% to -9.7%) and free T3 of 49.4% (95% CI, -93.7% to -5.1%) after radioiodine administration.

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Implication

Prospective clinical trial demonstrates hormone surges stem from stopping antithyroid drugs rather than radioiodine ablation, indicating radiation does not worsen thyrotoxicosis.

Cite This Study

Henry B. Burch (1994) studied this question.

synapsesocial.com/papers/6a846a09e22b852b8ec53d15 https://doi.org/10.7326/0003-4819-121-8-199410150-00001

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Implication

Prospective clinical trial demonstrates hormone surges stem from stopping antithyroid drugs rather than radioiodine ablation, indicating radiation does not worsen thyrotoxicosis.

Discontinuing Antithyroid Drug Therapy before Ablation with Radioiodine in Graves Disease

Key Points

Discussion

Implication

Cite This Study

Discontinuing Antithyroid Drug Therapy before Ablation with Radioiodine in Graves Disease

Key Points

Discussion

Implication

Cite This Study

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