Key result
Inflammatory bowel disease was associated with significantly higher thickness of bilateral carotid intima-media and epicardial adipose tissue compared to healthy controls (p < 0.05).
Why the study?
The study aimed to compare CIMT and EAT measurements, considered markers for detecting early atherosclerosis, between patients with IBD and healthy controls.
Are epicardial adipose tissue and carotid intima-media thickness increased in patients with inflammatory bowel disease compared to healthy controls?
Case-Control (n=120)
Are epicardial adipose tissue and carotid intima-media thickness increased in patients with inflammatory bowel disease compared to healthy controls?
Answers are grounded in this paper and cite their sources.
Inflammatory bowel disease is associated with increased epicardial adipose tissue and carotid intima-media thickness, suggesting these non-invasive imaging markers could help screen for early atherosclerotic risk in this population.
BACKGROUND AND AIM: this study aimed to compare carotid intima media (CIMT) and epicardial adipose tissue (EAT) measurements, which are considered as markers for the detection of early atherosclerosis in healthy controls and inflammatory bowel disease (IBD) cases. METHODS: a total of 60 IBD patients (25 Crohn's disease and 35 ulcerative colitis) and 60 healthy patients (as a control group) were included in the study. The measurements of CIMT and EAT were performed using echocardiography and ultrasonography, respectively. Statistical analysis was used to determine the relationship between the parameters. RESULTS: the thickness of bilateral (right and left) CIMT and EAT were significantly higher in IBD than in the control group (p < 0.05). There was a positive correlation between EAT and bilateral (right and left) CIMT in IBD patients (p < 0.05). CONCLUSION: IBD is associated with an increased thickness of EAT and CIMT. Chronic inflammation in IBD may increase the risk of atherosclerotic heart disease. Thus, only measuring the thickness of EAT and CIMT can be used as an objective, easy, simple, affordable, non-invasive and accessible assessment method in order to screen for this risk.
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Ekmen et al. (2020) conducted a case-control in Inflammatory bowel disease (n=120). Inflammatory bowel disease vs. Healthy controls was evaluated on Thickness of bilateral carotid intima media (CIMT) and epicardial adipose tissue (EAT) (p=< 0.05). Inflammatory bowel disease was associated with significantly higher thickness of bilateral carotid intima-media and epicardial adipose tissue compared to healthy controls (p < 0.05).
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