Key result
Patients with inflammatory bowel diseases showed significantly higher carotid intima-media thickness (SMD 0.534; 95% CI 0.230 to 0.838; P=.001) and lower flow-mediated dilation than controls.
Why the study?
Do patients with inflammatory bowel diseases have increased markers of subclinical atherosclerosis compared to controls?
Population
Patients with inflammatory bowel diseases (IBDs) and control groups across 28 studies
Comparison
Presence of inflammatory bowel disease (IBD) vs Control groups without IBD
Design
Meta-analysis
Authors
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May warrant closer CV surveillance in IBD; leaves open causality and whether interventions improve outcomes.
Meta-Analysis
Do patients with inflammatory bowel diseases have increased markers of subclinical atherosclerosis compared to controls?
Effect estimate: SMD 0.534 (95% CI 0.230 to 0.838)
p-value: p=.001
Patients with inflammatory bowel disease have an elevated cardiovascular burden as evidenced by significantly worse markers of subclinical atherosclerosis compared to controls.
Wu et al. (2016) conducted a meta-analysis in Inflammatory Bowel Diseases. Inflammatory Bowel Diseases vs. Controls was evaluated on Carotid intima-media thickness (CIMT) (SMD 0.534, 95% CI 0.230 to 0.838, p=.001). Patients with inflammatory bowel diseases showed significantly higher carotid intima-media thickness (SMD 0.534; 95% CI 0.230 to 0.838; P=.001) and lower flow-mediated dilation than controls.
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