Key result
Protocol outlines systematic review of inflammatory bowel disease effects on endothelial and vascular function.
Why the study?
Patients with inflammatory bowel disease might be at increased risk for cardiovascular disease, but the extent of CVD burden in IBD patients is unclear.
Systematic Review
Answers are grounded in this paper and cite their sources.
Protocol for meta-analyzing vascular dysfunction in IBD published; leaves open pooled effect sizes on endothelial function and arterial stiffness pending completion.
Introduction Patients with inflammatory bowel disease (IBD) might be at an increased risk for the development of cardiovascular disease (CVD). The present protocol is developed to review and analyse published data to determine if patients with IBD have an increased CVD burden. Methods and analysis We will conduct a systematic review of all observational studies that examine endothelial function, arterial stiffness and carotid intima-media thickness in patients with IBD. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and study quality will be assessed using the Newcastle-Ottawa Scale. If sufficient data are available, a meta-analysis will be conducted. The overall effect sizes will be estimated using both fixed effects models and random effects models. Statistical heterogeneity will be calculated using Higgin’s (I 2 ) tests. Subgroup analyses, conditional number of studies retrieved and their sample size, will be stratified according to participant disease category or gender or disease activity. Ethics and dissemination Formal ethics approval is not required as individual data will not be collected. The results will be disseminated through peer-reviewed publications, conference presentations and scientific news releases. PROSPERO registration number CRD42021274093.
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Wu et al. (2022) conducted a systematic review in Inflammatory bowel disease. Inflammatory bowel disease vs. Controls without IBD was evaluated on Endothelial function (FMD, NMD, RH-PAT), arterial stiffness (PWV, AIx), and carotid intima-media thickness (cIMT). Inflammatory bowel disease and its impact on endothelial function, arterial stiffness, and carotid intima-media thickness will be systematically reviewed according to this published protocol.
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