Key result
Inflammatory bowel disease was associated with significantly increased carotid intima-media thickness compared to matched controls (Cohen’s d 0.63).
Why the study?
Population-based studies suggested that patients with inflammatory bowel disease (IBD) might have an increased risk for cardiovascular diseases, prompting evaluation of endothelial function, arterial stiffness, and carotid intima-media thickness.
Does inflammatory bowel disease increase arterial stiffness and endothelial dysfunction compared to matched controls?
Meta-Analysis (n=4,362)
Yes
Does inflammatory bowel disease increase arterial stiffness and endothelial dysfunction compared to matched controls?
Answers are grounded in this paper and cite their sources.
Patients with inflammatory bowel disease exhibit surrogate markers of increased cardiovascular risk, including endothelial dysfunction and arterial stiffness, highlighting the need for aggressive cardiovascular risk stratification in this population.
Population-based studies have suggested that patients with inflammatory bowel disease (IBD) might be at an increased risk for cardiovascular diseases. A meta-analysis was performed on clinical studies to evaluate endothelial function, arterial stiffness, and carotid intima-media thickness (cIMT) in patients with IBD, after searching PubMed, Embase, Cochrane library, and Web of Science databases. A random-effects model was used to allow for the pooling of studies and for determination of the overall effect. After exclusion, a total of 41 eligible studies with 2330 patients with IBD and 2032 matched controls were identified and included for the analysis. It was found that cIMT was significantly increased in patients with IBD as compared with that in matched controls (Cohen’s d: 0.63; 95% CI: 0.34, 0.93; I2 = 91.84%). The carotid–femoral pulse wave velocity was significantly higher in patients with IBD compared to that in matched controls (Cohen’s d: 0.76; 95% CI: 0.54, 0.98; I2 = 70.03%). The augmentation index was also significantly increased in patients with IBD compared to matched control subjects (Cohen’s d: 0.35; 95% CI: 0.08, 0.63; I2 = 61.37%). Brachial artery flow-mediated dilatation was significantly decreased in patients with IBD than that in matched controls (Cohen’s d: −0.73; 95% CI: −1.10, −0.36; I2 = 81.02%). Based on the meta-analysis, it was found that patients with IBD exhibit significant endothelial dysfunction, increased arterial stiffness, and cIMT. Thus, patients with IBD may benefit from aggressive risk stratification for cardiovascular diseases.
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Wu et al. (2022) conducted a meta-analysis in Inflammatory Bowel Disease (n=4,362). Inflammatory Bowel Disease vs. Matched controls was evaluated on Carotid intima-media thickness (cIMT) (Cohen's d 0.63, 95% CI 0.34, 0.93, p=<0.01). Inflammatory bowel disease was associated with significantly increased carotid intima-media thickness compared to matched controls (Cohen’s d 0.63).
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